Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls -Peter Le

posted Aug 21, 2015, 12:27 AM by Peter Le
    The purpose of this research was to find if Leptin, IL-6, and suPAR was associated with adiposity, lipodystrophy, and low muscle mass in HIV-infected patients. HIV patients are able to exhibit accelerated aging. The authors objective was to study if leptin, IL-6, and suPAR ssociated with adiposity, lipodystrophy, and sarcopenia in HIV-infected patients. Inflammation is involved in age-associated complications, however it wasn't proven that the same inflammation change were involved. The results were that adiposity was associated with FMI and VAT, but not LMI. IL-6 was associated with FMI and VAT and low LMI while suPAR is associated with low LMI and weakly with high VAT and FMI. Leptin, IL-6, and suPAR can expand our understanding with imflammation processes that are involved with age. Leptin levels were higher in HIV-patients with lipodystrophy while there wasn't any difference in IL-6 or suPar levels.


Anne Langkilde, Janne Petersen, Jens Henrick Henricksen, Frank Kreiger Jensen, Jesper Eugen-Olsen, Ove Andersen, Jane Gersoft. "Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls" 21 Aug. 2015.
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